Human radiation dosimetry estimates were calculated using olindaexm 1. Olindaexm radiation dose assessment software application fda approved. Serial radionuclide imaging provides patient specific information for the individual nuclide kinetics in tumors and normal organs to an administered dose. Hermes medical solutions and vanderbilt university announced the signature of an exclusive license and commercialization agreement for the new dosimetry application olinda exm 2. Jan 29, 2020 patientadjusted and scanspecific information was extracted from the electronic medical record and scanner dosemonitoring software.
Mar 07, 2012 olindaexm utilizes radionuclide decay data from brookhaven national laboratory as documented in stabin and da luz 2002. The results showed that the residence times and absorbed doses. Abstract 60 comparison of organbased absorbed doses. The df values on the radar site report simply the absorbed dose mgy per disintegration for source and target organs. S value ratios for all selfdose irradiation scenarios were observed. Evaluation of radiation dosimetry of 99m tchynicpsma and. Radiation dosimetry of 18fpss232a pet radioligand for. Development of a software tool for an internal dosimetry using mird method. All dosimetric calculations were done using the olindaexm 1. In this work, a userfriendly javabased opensource software has been. I need internal dosimetry software for nuclear medicne.
We offer a manager interface with permission control, easy upload of videos and pdfs, downloadable certificates of completion, realtime reporting, and a shopify integration for ecommerce capability. Appropriate approvals for version 2 are being obtained. Olindaexm version 1 was extensively betatested prior to release, and has been. Dosimetric analyses of kidneys, liver, spleen, pituitary. Icrp 30 gastrointestinal model was used for simulation of 15% of liver and 50% of gall. Looking for online definition of mird or what mird stands for. The total administered activity is determined by organ dose limits kidneys and bone marrow, and our aim therefore was to compare and. The calculated equivalent dose and effective dose for organs were reported. Choose the most popular programs from system tools. Patientadapted organ absorbed dose and effective dose.
The calculated doses were in good agreement with the arsac published values. Jun 10, 2017 stockholm june 10, 2017 hermes medical solutions launches hybrid dosimetry and olinda exm 2. The olindaexm personal computer code for calculating organ doses and. Jun 27, 2019 olinda exm is a personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004. Among the organs, the urinary bladder received the largest absorbed dose 94. Radar has developed a new version of the olinda exm software stabin et al 2005 that. Network accelerates innovation by allowing you to discover and connect to gamechanging technologies and technology professionals on the worlds most comprehensive technology network. Can anyone provide me any software, except olinda exm its not available at the moment.
Please visit the main page of olinda exm on software informer. The visual monte carlo program external dose monte carlo. Olinda exm version 1 was extensively betatested prior to release, and has been granted a fda 510k k03396 by the us food and drug administration as a software device. Olindaexm version 1 was extensively betatested prior to release, and has been granted a fda 510k k03396 by the us food and drug administration as a software device.
The olindaexm personal computer code for calculating organ doses and effective. Pharmacokinetic, dosimetry and toxicity study of 177 luedtmp. Comparison of 111indtpa0octreotide versus non carrier. A detailed instruction manual including implementation tests is supplied with the software. Olinda exm, which stands for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on user. A dosimetry procedure for organsatrisk in 177lu peptide. Timeactivity curves were generated, and the residence times were calculated. Olinda exm is a personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004. The implementation tests describe a series of sample problems that can be run to ensure the correct installation of the soft ware.
Hermes medical solutions hermes by sofia bertling coo and vanderbilt university. Can anyone provide me any software, except olindaexm its not available at the moment. Volume delineation of critical organs such as renal cortex, liver. Each patient underwent a series of 9 wholebody scans at 30 minutes prevoid and 4, 8, 12, 24, 48, 96, 144, and 168 h.
Hermes medical solutions and vanderbilt university announce exclusive license and commercialization agreement. This paper documents the basic function of the code and how it is similar to and different from the mirdose software. Radiation dose to the fetus from 18ffdg administration. Update on the release and availability of olinda version 2. Ct dose was calculated using patientspecific data in impact.
In a phase 0 study, the biokinetics of skeletal and nonskeletal uptake of 177 luedtmp was assessed in 6 patients with metastatic prostate cancer using tracer doses 172. For this purpose, we developed an idlbased software package for integrated data processing for internal dose assessment in nuclear medicine sprind. Internal radiation dosimetry of orally administered. From the concentrations of radioactivity measured on the images, the timeintegrated activity coefficients of the fetus and the placenta were derived. Evaluation of 18ffnm biodistribution and dosimetry based on.
Results physiological uptake of 177 ludotatate was seen in all patients in kidneys, liver, spleen, and pituitary gland. Since i am forced to use window for this software, i am just double clicking the shortcut to execute the javaw. Michael stabin, associate professor of radiology and radiological sciences at. The most popular version of this product among our users is 1. Olinda exm radiation dose assessment software application fda approved. If excretion of the radiotracer is prevented, the total residence time, which is the summation of the residence times in all of the organs in the body and the remainder of the body, can be calculated using the following.
I am interested to purchase an internal dosimetry software for. However, these software packages do not calculate residence times from image data. Development of a software tool for an internal dosimetry. Choline c 11 fda prescribing information, side effects and uses. Technology olindaexm radiation dose assessment software. The radiation doses among 153 sm, 111 in and 99m tc formulations were compared.
The radiation absorbed doses estimated for adult patients following intravenous injection of axumin are shown in table 1. Olindaexm radiation dose assessment software application. Mird is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms. Objectives the olinda exm code developed by the radiation dose assessment resource radar task group of the society of nuclear medicine has standardized dose calculations for diagnostic and therapeutic radiopharmaceuticals. K03396 by the us food and drug administration as a software device. Two software available on the market can be used to compare organbased absorbed doses, the new version of olinda exm olinda v2 within hermes workstation and planet dose pdose from dosisoft. Description of the device that is subject of this premarket notification. A product demo of the organ level internal dose assessmentexponential modeling olindaexm developed by dr. Selected comparisons between 99m tc s values computed by the olinda exm 1. Radiopharmadose, a javabased opensource software for. Biodistribution and radiation dosimetry of 11cnicotine. Nov 01, 2019 the estimated radiation absorbed doses for adults from intravenous injection of choline c 11 injection are shown in table 1.
Olindaexm radar the radiation dose assessment resource. Biodistribution and radiation dosimetry of the novel hypoxia. Impact of icrp89 based models on dose estimates for. The installation guide for olinda exm tells me to use the javaw. Data of whole skeletal uptake, blood and fractionated urine samples were obtained and dosimetric calculations were performed using the olindaexm 1. These estimates are calculated from data in tolvanen 1 and using olindaexm organ level internal dose assessmentexponential modeling software from vanderbilt university. Olindaexm organ level internal dose assessmentexponential. The program has phantom libraries which permit the calculation of these doses for individuals of different age and size and for women at different stages of pregnancy. Vu0338olindaexm radiation dose assessment software. Values were calculated from human biodistribution data using olinda exm organ level internal dose assessmentexponential modeling software. The absorbed radiation dose for the whole body was calculated by entering the residence time in olindaexm 1. Ffdrsiglec9 were calculated with the olinda exm version 1. At the cancer research institute of montpellier the first patients were treated during 2016. Pet dose was calculated by modifying the standard reference phantoms in olinda exm 1.
A physiological uptake of 68gadotanoc was seen in all patients in the pituitary gland, the spleen, the liver, and the urinary tract kidneys and urinary bladder. The radiochemical yield was optimized and was 27 7%, with an average activity of 18 ffnm of 3940 1600 mbq. Olinda exm radiation dose assessment software application. Olinda exm runs on windows2000 or windowsxpbased personal computers, with 256 mb ram, and 100 mb free space on the primary hard disk. Jan 16, 2015 a product demo of the organ level internal dose assessmentexponential modeling olindaexm developed by dr. Can anyone provide me any software, except olindaexm its not available at. The goal of this work is to compare organbased absorbed dose estimations by using the local energy deposit approach leda. This paper documents the basic function of the code and how it is similar to and different from the mirdose.
Sep 14, 2007 dosimetric evaluations were done using the olindaexm 1. Dosimetric analyses of kidneys, liver, spleen, pituitary gla. Evaluation of 18ffnm biodistribution and dosimetry based. The wholebody mean effective dose of 18 fdifa estimated by using the medical internal radiation dose mird schema with organ level internal dose assessmentexponential modeling olindaexm computer software 1. The authors estimated the fetal radiation dose from 18 ffdg in a rare case of a woman who underwent a petct scan during the second trimester of pregnancy. N data were the input for the olinda exm code to calculate internal radiation doses. No bladdervoiding model was used because of the lipophilic structure and dominantly excretion through the biliary system. Richard sparks and eric crowe, of cde dosimetry services, inc. The radiation transport phantom selected from olindaexm 1. The computed tiacs were introduced in the olinda exm software for kidneys, spleen, liver, red marrow and remainder of the body.
Olindaexm runs on windows2000 or windowsxpbased personal computers, with 256 mb ram, and 100 mb free space on the primary hard disk. The organs included in dosimetric calculation were kidney, liver, spleen, pituitary gland, and nets. For dealing with svalues, the freeware packages mirdose and, more recently, olinda exm are available. Olinda exm, which stands for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on usersupplied biokinetic. A physiological uptake of 68 gadotanoc was seen in all patients in the pituitary gland, the spleen, the liver, and the urinary tract kidneys and urinary bladder. Dosimetric evaluations were done using the olindaexm 1. Methods after creation of the code and alpha and betatesting phases, a premarket notification submission 510k was filed with the food and drug. The patient, a 27yold female with a paraganglioma, received 181. In this work, a userfriendly javabased opensource software has. This paper documents the basic function of the code and how it is similar to and. Results a physiological uptake of 68 gadotanoc was seen in all patients in the pituitary gland, the spleen, the liver, and the urinary tract kidneys and urinary bladder. The secondgeneration personal computer software for internal dose assessment in nuclear medicine michael g. Impact of icrp89 based models on dose estimates for radiopharmaceuticals and ct exams.
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